Extract patch (p28574555_122010_MSWIN-x86-64.zip) to a folder (C:\)
set ORACLE_HOME=C:\Oracle\product\12.2.0\dbhome_1
set PATH=%ORACLE_HOME%\bin;%ORACLE_HOME%\OPatch
cd C:\p28574555_122010_MSWIN-x86-64\28574555
stop all Oracle instances
opatch apply
if everything went ok: “OPatch succeeded.”